Evans P D, Reale V, Merzon R M, Villegas J
Department of Zoology, University of Cambridge, United Kingdom.
J Exp Biol. 1992 Dec;173:229-49. doi: 10.1242/jeb.173.1.229.
L-Glutamate application can produce three different responses in the membrane potential of the Schwann cell of the tropical squid, Sepioteuthis sepioidea, which appear to be mediated by three pharmacologically distinct classes of receptor. A class of non-NMDA-type receptors, with some similarities to metabotropic glutamate receptors, mediates the development of a rapid and long-lasting hyperpolarization. Two pharmacologically distinct classes of NMDA-type receptor are present. One mediates the development of a slow depolarization accompanied by a long-lasting change in responsiveness of the Schwann cell. The second produces rapid depolarizing responses during the period of this changed responsiveness. All three types of receptor can be activated by dipeptides containing excitatory amino acids.
在热带鱿鱼（Sepioteuthis sepioidea）的雪旺氏细胞膜电位中，L-谷氨酸的应用可产生三种不同的反应，这三种反应似乎由三类药理学特性不同的受体介导。一类非NMDA型受体，与代谢型谷氨酸受体有一些相似之处，介导快速且持久的超极化的产生。存在两类药理学特性不同的NMDA型受体。一类介导缓慢去极化的产生，并伴有雪旺氏细胞反应性的长期变化。第二类在这种反应性改变期间产生快速去极化反应。所有这三种类型的受体都可被含兴奋性氨基酸的二肽激活。
