Beltrutti D P, Ardizzone A, Parola P
Department of Anaesthesia, Santa Croce General Hospital, Cuneo, Italy.
Panminerva Med. 1992 Jul-Sep;34(3):128-34.
Chronic pain in patients suffering from advanced cancer as well as unbearable chronic pain states depending on non-malignant pathology have always represented a test bench to verify results of advanced therapeutical programs as to more traditional approaches. The Authors present their experience resulting from longterm spinal infusion with peridural catheters connected to portable micropumps for the continuous administration of analgesic solutions. The availability of portable micropumps, a better understanding of spinal opioid receptors and advances in pharmacokinetics of opiate analgesics led in these years to a tremendous improvement of pain control possibilities and of the quality of life of patients.
晚期癌症患者的慢性疼痛以及取决于非恶性病理的难以忍受的慢性疼痛状态，一直是验证先进治疗方案相对于传统方法效果的试验台。作者介绍了他们长期通过硬膜外导管连接便携式微型泵进行脊髓输注以持续给予镇痛溶液的经验。便携式微型泵的出现、对脊髓阿片受体的更好理解以及阿片类镇痛药药代动力学的进展，近年来极大地改善了疼痛控制的可能性以及患者的生活质量。
