Neurotransmitter releasing action of 6R-tetrahydrobiopterin.
作者信息
Koshimura K, Ohue T, Watanabe Y, Miwa S
机构信息
Department of Pharmacology, Kyoto University Faculty of Medicine, Japan.
出版信息
J Nutr Sci Vitaminol (Tokyo). 1992;Spec No:505-9. doi: 10.3177/jnsv.38.special_505.
PMID:1363668
Abstract
We showed that 6R-BH4, a natural cofactor for aromatic amino acids hydroxylases, can stimulate exocytotic DA release independently of its cofactor activity, and ACh release via monoaminergic system. From these results, it is quite likely that 6R-BH4 plays an important role in the regulation of neuronal activity, as a modulator of neurotransmitter release as well as a cofactor for hydroxylases.
摘要
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