Morris A I
Dept. of Gastroenterology, Royal Liverpool University Hospital, U.K.
Scand J Gastroenterol Suppl. 1992;194:71-5. doi: 10.3109/00365529209096031.
The lives of both patients and doctors have been revolutionized since the development of histamine-2 receptor antagonists. Their development has introduced, for the first time, a rapid, reliable, and save means of healing both duodenal and gastric ulceration. The continuous administration of these agents has additionally been shown to reduce ulcer relapse and subsequent complications. In addition, they offer some protection from the development of nonsteroidal anti-inflammatory drug-induced damage. The symptomatic relief of reflux together with healing of oesophagitis has been of further benefit. The drugs in this group have become one of the most widely used ethical pharmaceuticals in the world, with ranitidine (Zantac) as the biggest-selling drug in the world for the last few years. Their success can be attributed to their simplicity of use, safety, and above all, their efficacy. Their current role in gastroenterologic practice, in the face of new developments such as Helicobacter eradication and the development of proton pump inhibitors, will be discussed.
自从组胺-2受体拮抗剂问世以来，患者和医生的生活都发生了翻天覆地的变化。它们的出现首次带来了一种快速、可靠且安全的治愈十二指肠溃疡和胃溃疡的方法。持续使用这些药物还被证明可以减少溃疡复发及后续并发症。此外，它们还能在一定程度上预防非甾体抗炎药所致损伤的发生。缓解反流症状并治愈食管炎更是带来了额外的益处。该类药物已成为世界上使用最广泛的处方药之一，雷尼替丁（善胃得）在过去几年一直是全球销量最大的药物。它们的成功得益于使用简便、安全性高，尤其是疗效显著。面对根除幽门螺杆菌和质子泵抑制剂等新进展，将讨论它们目前在胃肠病学实践中的作用。
