Maillier B, Chapoutot L, Metz D, Bailly L, Reksa A, Sal R, Elaerts J, Bajolet A
Service de Cardiologie, CHU Reims, Cedex.
Ann Cardiol Angeiol (Paris). 1992 Oct;41(8):433-5.
The authors report a case of anaphylactic shock complicated by coronary spasm and infarction attributed to glafenine medication in a 43-year-old male patient. The outcome was positive and coronary angiography showed healthy coronary vessels. The ergonovine maleate was negative. A review of the literature confirms the rarity of this complication of anaphylactic shock and study the ECG changes induced by this type of reaction and to analyze the mechanisms responsible for this coronary spasm in this situation. These consists basically of histamine release and prostaglandin-synthesis inhibition.
作者报告了一例43岁男性患者因服用格拉非宁药物导致过敏性休克并发冠状动脉痉挛和梗死的病例。结果良好，冠状动脉造影显示冠状动脉血管正常。马来酸麦角新碱试验为阴性。文献回顾证实了这种过敏性休克并发症的罕见性，并研究了此类反应引起的心电图变化，分析了这种情况下冠状动脉痉挛的机制。这些机制主要包括组胺释放和前列腺素合成抑制。
