Oliveros L, Minguillon C, Billaud C
Laboratoire de Chimie Générale (CNRS URA 1103), Paris, France.
J Pharm Biomed Anal. 1992 Oct-Dec;10(10-12):925-30. doi: 10.1016/0731-7085(91)80100-n.
The resolution of four racemic 3-hydroxy-1,4-benzodiazepin-2-ones, widely used in therapeutics, by means of a chiral stationary phase is described. The chiral selector used is (S)-N-(3,5-dinitrobenzoyl)phenylalanine. This chiral stationary phase showed both good enantioselectivity and efficiency for the compounds. Elution times were in all cases shorter than those previously reported for such compounds on different stationary phases. Racemic oxazepam was used to evaluate the loading capacity of the chiral stationary phase.
描述了通过手性固定相拆分四种广泛用于治疗的外消旋3-羟基-1,4-苯并二氮杂卓-2-酮的方法。所使用的手性选择剂是(S)-N-(3,5-二硝基苯甲酰基)苯丙氨酸。该手性固定相对这些化合物显示出良好的对映体选择性和分离效率。在所有情况下，洗脱时间均短于先前报道的这些化合物在不同固定相上的洗脱时间。使用外消旋奥沙西泮评估手性固定相的负载量。
