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单核细胞及其亚群对体外淋巴细胞增殖的免疫调节。II. 用抗原和丝裂原激活的培养物中T细胞的表型变化。

Immunoregulation of lymphoproliferation in vitro by monocytes and their subpopulations. II. Phenotypic changes of T cells in cultures activated with antigen and mitogen.

作者信息

Pryjma J, Kowalczyk D, Ruggiero I, Zembala M

机构信息

Department of Clinical Immunology and Microbiology, Copernicus Medical School, Cracow, Poland.

出版信息

Arch Immunol Ther Exp (Warsz). 1992;40(2):139-43.

PMID:1363714
Abstract

The aim of this study was to analyze phenotypes of T cells activated by mitogen (PWM) and antigen (PPD) in the presence of FcR+ or FcR- monocytes. It was found that CD4+ and CD8+ lymphocytes are preferentially activated in the presence of different monocyte subpopulations. Expression of HLA-DR and CD25 on CD4+ lymphocytes was greater in cultures activated in the presence of FcR-. CD8+ lymphocytes were more efficiently activated (expression of HLA-DR) when FcR+ monocytes were added to culture. In the presence of FcR+ monocytes an increased expression of CD45RA antigen on CD4+ cells was also observed. These data support our previous functional studies which showed that "suppressor" T cells of CD8+ phenotype are activated in the presence of FcR+ monocytes.

摘要

本研究的目的是分析在存在FcR+或FcR-单核细胞的情况下，由丝裂原（PWM）和抗原（PPD）激活的T细胞的表型。结果发现，在不同单核细胞亚群存在的情况下，CD4+和CD8+淋巴细胞优先被激活。在FcR-存在的情况下激活的培养物中，CD4+淋巴细胞上HLA-DR和CD25的表达更高。当将FcR+单核细胞添加到培养物中时，CD8+淋巴细胞被更有效地激活（HLA-DR的表达）。在FcR+单核细胞存在的情况下，还观察到CD4+细胞上CD45RA抗原的表达增加。这些数据支持了我们之前的功能研究，该研究表明CD8+表型的“抑制性”T细胞在FcR+单核细胞存在的情况下被激活。

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