David D, Mergulhão C, Capucho I, Lavinha J
Laboratório de Genética Humana, Instituto Nacional de Saúde Dr Ricardo Jorge, Lisboa, Portugal.
Gene Geogr. 1992 Apr-Aug;6(1-2):79-84.
We have determined the allele frequencies of seven restriction fragment length polymorphisms within or close to factor VIII:C gene in the Portuguese population. The allele frequency of all studied intra- and extragenic biallelic polymorphisms does not differ significantly from those found in other European or Asian populations. On the contrary, the distribution of the different alleles of the TaqI RFLP at the DXS52 locus revealed similarity only with Algerians. We observed a correspondence between the TaqI and BclI alleles at this locus.
我们已经确定了葡萄牙人群中凝血因子VIII:C基因内部或附近七个限制性片段长度多态性的等位基因频率。所有研究的基因内和基因外双等位基因多态性的等位基因频率与在其他欧洲或亚洲人群中发现的频率没有显著差异。相反，DXS52位点TaqI限制性片段长度多态性的不同等位基因分布仅与阿尔及利亚人相似。我们观察到该位点TaqI和BclI等位基因之间存在对应关系。
