Wang R H, Dillon J, Reme C, Whitt R, Roberts J E
Columbia University, NY.
Lens Eye Toxic Res. 1992;9(3-4):483-91.
Light Therapy is a new treatment for patients with Seasonal Affective Disorder (SAD), a depressive state occurring during the winter as a result of decreased sunlight. The treatment involves placing the patient in front of a light box (2-10,000 lux) for approximately 30 min to 1 hour per day during the winter months. Although there have been no reports of damage to the eye from this treatment with light alone there is increased risk in light damage to the lens and retina if these depressed patients are being treated with antidepressant/neuroleptic drugs concurrently with their light therapy. As we have been previously reported certain drugs, having absorptions longer than 295 nm can act as photosensitizers resulting in enhanced light damage to the eye. Using a screening method developed by Roberts, we examined the potential phototoxicity of a variety of antidepressant and neuroleptic drugs.
光疗法是治疗季节性情感障碍（SAD）患者的一种新方法。季节性情感障碍是一种在冬季因日照减少而出现的抑郁状态。治疗方法是在冬季的几个月里，让患者每天在光盒（2000 - 10000勒克斯）前坐大约30分钟到1小时。虽然尚无仅用这种光疗法导致眼睛损伤的报告，但如果这些抑郁症患者在接受光疗的同时还服用抗抑郁药/抗精神病药物，那么晶状体和视网膜受到光损伤的风险就会增加。正如我们之前所报道的，某些吸收波长大于295纳米的药物可作为光敏剂，从而增强对眼睛的光损伤。我们使用罗伯茨开发的一种筛查方法，检测了多种抗抑郁药和抗精神病药物的潜在光毒性。
