Tanizawa H, Terada M, Watanabe Y
Nihon Yakurigaku Zasshi. 1976 Jul;72(5):493-9.
We have shown previously that 4-iodothymol (IT) produces a contraction in Ascaris muscle, probably due to the myogenic action. In this paper, the effects of IT on the carbohydrate metabolism in Ascaris muscle have been investigated in comparison with those of hexylresorcinol (Hex), santonin (S) and piperazine (Pip). (1) Hex (200 approximately 400 mug/ml) showed a strong nonspecific inhibition on the formation of succinate from fumarate in muscle homogenate, the phosphofructokinase (PFK) activity in cytoplasm, and the electron transfer activity in mitochondria. (2) S(100 approximately 400 mug/ml) and Pip (100 approximately 400 mug/ml) were inneffective on these activities. (3) IT inhibited the formation of succinate from glucose and fumarate in muscle homogenate (100 approximately 400 mug/ml), the PFK activity in cytoplasm (400 mug/ml), and the mitochondrial succinate oxidase system (25 approximately 400 mug/ml). These results suggest that IT elicits the wormcidal action by inhibiting the energy metabolism of Ascaris muscle mitochondria.
我们之前已经表明，4-碘百里酚（IT）可使蛔虫肌肉产生收缩，这可能是由于其肌源性作用。在本文中，已将IT对蛔虫肌肉碳水化合物代谢的影响与己基间苯二酚（Hex）、山道年（S）和哌嗪（Pip）的影响进行了比较研究。（1）Hex（200约400微克/毫升）对肌肉匀浆中富马酸生成琥珀酸、细胞质中的磷酸果糖激酶（PFK）活性以及线粒体中的电子传递活性表现出强烈的非特异性抑制作用。（2）S（100约400微克/毫升）和Pip（100约400微克/毫升）对这些活性无作用。（3）IT抑制肌肉匀浆中葡萄糖和富马酸生成琥珀酸（100约400微克/毫升）、细胞质中的PFK活性（400微克/毫升）以及线粒体琥珀酸氧化酶系统（25约400微克/毫升）。这些结果表明，IT通过抑制蛔虫肌肉线粒体的能量代谢引发驱虫作用。
