Diringer H
Robert-Koch-Institut des Bundesgesundheitsamtes, Berlin, FRG.
Exp Clin Immunogenet. 1992;9(4):212-29.
The pathogenesis as well as the genetic disposition to develop clinical symptoms in transmissible spongiform encephalopathies (e.g. Creutzfeldt-Jakob disease, scrapie, bovine spongiform encephalopathy) relate these diseases to classical noninfectious amyloidoses (familial amyloidotic polyneuropathy as an example) and to Alzheimer's disease. This is not obvious to the nonexpert at first glance. This communication tries to elucidate this association, to reveal which immunochemical techniques have contributed their share.
可传播性海绵状脑病（如克雅氏病、羊瘙痒病、牛海绵状脑病）的发病机制以及出现临床症状的遗传倾向，将这些疾病与典型的非感染性淀粉样变性病（例如家族性淀粉样多神经病）以及阿尔茨海默病联系了起来。乍一看，这对非专业人士来说并不明显。本交流旨在阐明这种关联，揭示哪些免疫化学技术发挥了作用。
