小鼠皮肤移植免疫与体液同种抗体形成之间的关系。
Relationship between skin transplantation immunity and the formation of humoral isoantibodies in mice.
作者信息
HILDEMANN W H, MEDAWAR P B
出版信息
Immunology. 1959 Jan;2(1):44-52.
Abstract
Crude splenic nuclear fractions can incite skin transplantation immunity in mice without producing a detectable titre of haemagglutinins or haemolysins, and have little if any power to absorb antibodies from sera in which they have been caused to appear by other means. Antigenic preparations of other kinds can incite iso-antibody formation unaccompanied by transplantation immunity. Thus humoral iso-antibodies can be present when transplantation immunity is absent and absent when it is present. Transplantation immunity and serum antibody production probably depend upon different immunological processes, even if they eventually prove to be elicited by antigens with the same or similar determinant groups.
摘要
粗制脾脏核组分可在小鼠中引发皮肤移植免疫反应，而不会产生可检测到的血凝素或溶血素滴度，并且几乎没有（如果有的话）从通过其他方式使其出现的血清中吸收抗体的能力。其他种类的抗原制剂可引发同种抗体形成，而不伴有移植免疫反应。因此，在没有移植免疫时可能存在体液同种抗体，而在存在移植免疫时则不存在。移植免疫和血清抗体产生可能取决于不同的免疫过程，即使最终证明它们是由具有相同或相似决定簇基团的抗原引发的。
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