Kitazume H, Ageishi Y, Iwama T, Kubo I
Department of Medicine, Bokuto Hospital, Tokyo.
J Cardiol. 1992;22(2-3):391-5.
Denopamine (15 mg/day) was administered to 20 patients with residual left ventricular dysfunction after successful percutaneous transluminal coronary angioplasty (75% or more diameter stenosis). Echocardiography was performed before and 6 months after denopamine administration to analyze the left ventricular function. There were significant decreases in both end-diastolic and end-systolic dimensions from 58 +/- 8.3 to 54 +/- 8.4 mm (p = 0.001), and from 44 +/- 10.1 to 40 +/- 10.3 mm (p = 0.005)), respectively, while % fractional shortening remained nearly constant (from 25 +/- 8.3 to 27 +/- 9.6%). Thus, denopamine improved the left ventricular function by decreasing left ventricular size while maintaining wall contractility.
对20例经皮腔内冠状动脉成形术成功（直径狭窄75%或以上）后仍有左心室功能不全的患者给予多巴胺（15毫克/天）。在给予多巴胺之前及给药6个月后进行超声心动图检查，以分析左心室功能。舒张末期和收缩末期内径分别从58±8.3毫米显著减小至54±8.4毫米（p = 0.001），以及从44±10.1毫米减小至40±10.3毫米（p = 0.005），而缩短分数百分比几乎保持不变（从25±8.3%至27±9.6%）。因此，多巴胺通过减小左心室大小同时维持室壁收缩力来改善左心室功能。
