免疫γ球蛋白和补体对克雷布斯腹水肿瘤细胞的细胞毒性作用。I. 超微结构研究。
The cytotoxic action of immune gamma globulin and complement on Krebs ascites tumor cells. I. Ultrastructural studies.
作者信息
GOLDBERG B, GREEN H
出版信息
J Exp Med. 1959 May 1;109(5):505-10. doi: 10.1084/jem.109.5.505.
Abstract
Electron microscopic studies of Krebs ascites tumor cells treated in vitro with rabbit immune gamma globulin revealed a distinctive alteration in the structure of the cellular surface membrane. The subsequent addition of complement to this system severely damaged the cytoplasmic matrix, mitochondria, and endoplasmic reticulum. This sequence of events provides a structural basis for the cytotoxic action of antibody and complement.
摘要
对用兔免疫γ球蛋白进行体外处理的克雷布斯腹水肿瘤细胞进行的电子显微镜研究显示，细胞表面膜的结构发生了显著改变。随后向该系统中添加补体，严重损害了细胞质基质、线粒体和内质网。这一系列事件为抗体和补体的细胞毒性作用提供了结构基础。
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