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[L-组氨酸对过氧化氢体外诱导8-羟基脱氧鸟苷形成的增强作用]

[Enhancing effect of L-histidine on the formation of 8-hydroxy-deoxyguanosine induced by hydrogen peroxide in vitro].

作者信息

Takagi A, Sai K, Hasegawa R, Kurokawa Y

出版信息

Eisei Shikenjo Hokoku. 1991(109):113-5.

PMID:1364376
Abstract

Treatment of deoxyguanosine with H2O2 (56 mM) at 37 degrees C for 2 hrs resulted in the formation of 8-hydroxydeoxyguanosine (8-OH-dG). The formation of 8-OH-dG by H2O2 was increased about 3-folds in the presence of 78 microM L-histidine (L-His). The result suggests that oxidative DNA damage induced by H2O2 in vitro might be enhanced by L-His.

摘要

在37摄氏度下，用56毫摩尔的过氧化氢处理脱氧鸟苷2小时，会导致8-羟基脱氧鸟苷（8-OH-dG）的形成。在存在78微摩尔L-组氨酸（L-His）的情况下，过氧化氢导致的8-OH-dG的形成增加了约3倍。结果表明，L-组氨酸可能会增强过氧化氢在体外诱导的氧化性DNA损伤。

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