Tanaka R, Usami M, Kawashima K, Takanaka A
Eisei Shikenjo Hokoku. 1992(110):22-6.
p-tert-Butylphenolformaldehyde resin, an adhesive, was given orally to pregnant Wistar rats by stomach intubation at the dose levels of 250, 500 and 1000 mg/kg body weight during days 7 to 17 of gestation, and the effects of the compound on dams and fetal developments were examined. No changes in general conditions, maternal body weight, food consumption, numbers of corpora lutea and implantation ratio were observed. There was no evidence of an increase in fetal death or of malformation attributable to the treatment with p-tert-butylphenolformaldehyde resin in any of dose levels examined. It was concluded that p-tert-butylphenolformaldehyde resin has no teratogenic effect in rats.
对叔丁基苯酚甲醛树脂是一种粘合剂，在妊娠第7至17天期间，通过胃插管以250、500和1000mg/kg体重的剂量水平口服给予怀孕的Wistar大鼠，并检查该化合物对母鼠和胎儿发育的影响。未观察到一般状况、母鼠体重、食物摄入量、黄体数量和着床率有变化。在所检查的任何剂量水平下，均没有证据表明对叔丁基苯酚甲醛树脂处理会导致胎儿死亡增加或畸形。得出的结论是，对叔丁基苯酚甲醛树脂对大鼠没有致畸作用。
