对反馈控制的干扰；一种抗代谢物作用机制。
Interference with feedback control; a mechanism of antimetabolite action.
作者信息
MOYED H S, FRIEDMAN M
出版信息
Science. 1959 Apr 10;129(3354):968-9. doi: 10.1126/science.129.3354.968.
PMID:13646630
Abstract
The action of an enzyme essential for tryptophan biosynthesis is inhibited by tryptophan and also by an analog of tryptophan. Similarly, histidine and one of its analogs inhibit the action of an enzyme essential for histidine biosynthesis. A mutant resistant to the histidine analog produces an apparently altered enzyme which is insensitive to both the analog and histidine.
摘要
色氨酸生物合成所必需的一种酶的活性受到色氨酸及其一种类似物的抑制。同样，组氨酸及其一种类似物抑制组氨酸生物合成所必需的一种酶的活性。对组氨酸类似物具有抗性的一个突变体产生了一种明显改变的酶，该酶对类似物和组氨酸均不敏感。
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