Rooney W
World Health Organization, Bangkok, Thailand.
Southeast Asian J Trop Med Public Health. 1992 Sep;23 Suppl 4:131-7.
Since the initial report of resistance of Plasmodium falciparum to chloroquine in 1960 in the Thai-Cambodian border resistance to alternative drugs occurred early after their introduction. This development is considered to be the result of population migration and excessive drug pressure along with the presence of a multi-resistance gene within the parasite population. Multi-resistant strains as such have been disseminated throughout the country by returning migrant populations.
自1960年首次报告柬埔寨与泰国边境地区恶性疟原虫对氯喹耐药以来，替代药物在投入使用后不久便出现了耐药情况。这种情况被认为是人口迁移、药物压力过大以及寄生虫群体中存在多重耐药基因共同作用的结果。这类多重耐药菌株已随外出务工人员返乡而在全国范围内传播开来。
