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重铬酸钾对白鼠睾丸组织病理学变化的影响及皮毛原子吸收光谱分析结果

[Effect of potassium dichromate on histopathologic changes in testicles of white rats and results of atomic pilograms on fur].

作者信息

Bulikowski W, Woźniak F, Borzecki Z, Radomska K, Kaliszuk K, Swies Z

机构信息

Przychodnia Zakładów Garbarskich w Gnieźnie.

出版信息

Ann Univ Mariae Curie Sklodowska Med. 1991;46:69-73.

PMID:1365005
Abstract

Male rats were administered, for the period of 30 days, potassium dichromate (K2Cr2O7) in a dose of 2 and 5 mg/kg of body weight and magnesium chloride (Mg Cl2) in a dose of 500 mg/kg of body weight. These two substances were also administered jointly (K2C2O7-5 mg/kg and MgCl2-500 mg/kg of body weight). In the testicles of animals receiving K2Cr2O7 in a dose of 5 mg/kg of body weight in groups III and IV there were observed changes of significant degree, mainly degenerative and multifocal, which consisted in degenerative changes of various degrees and changes of necrotic epithelium cells which, in turn, consist in cell hyper- or hypochromasia of chromatolysis or pycnosis and, too, in lesions of testicle epithelium of the spermatic epithelium cells. The cells of the Leydig intraparenchymatous gland did not reveal any histopathological changes as well as changes in the increase of hyatochemical tests. The highest concentration of chrome was in the hair of the animals receiving K2Cr2O7 in a dose of 5 mg/kg of body weight.

摘要

雄性大鼠在30天的时间里,分别以2毫克/千克和5毫克/千克体重的剂量给予重铬酸钾(K2Cr2O7),以500毫克/千克体重的剂量给予氯化镁(MgCl2)。这两种物质也联合给药(K2C2O7 - 5毫克/千克和MgCl2 - 500毫克/千克体重)。在第III组和第IV组中,接受5毫克/千克体重剂量K2Cr2O7的动物睾丸中观察到显著程度的变化,主要是退行性和多灶性的,包括不同程度的退行性变化以及坏死上皮细胞的变化,后者又包括染色质溶解或固缩的细胞高色素或低色素变化,以及精上皮细胞的睾丸上皮病变。间质内Leydig腺细胞未显示任何组织病理学变化以及组织化学检测增加的变化。铬浓度最高的是接受5毫克/千克体重剂量K2Cr2O7的动物毛发。

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