Woźniak F, Borzecki Z, Swies Z
Katedra i Zakład Patomorfologii. Akademia Medyczna w Lublinie.
Ann Univ Mariae Curie Sklodowska Med. 1991;46:65-8.
The rats were given potassium bichromate (K2Cr2O7) in dose of 2 and 5 mg/kg of body weight and magnesium chloride (MgCl2) in dose of 500 mg/kg for a period of 30 days. The two compounds were also given conjointly (K2Cr2O7-5 mg+MgCl2-500 mg). There were carried out histopathological as well as histochemical examinations of acid phosphatase activity, alkaline phosphatase activity and adenosine triphosphatase activity in the liver. With small doses (2 mg) of potassium bichromate no changes have been stated. With larger doses (5 mg) of potassium bichromate an increase of histochemical reaction to acid phosphatase as well as forming of histopathological changes such as parenchymatous degeneration, steatosis of hepatocytes and their necrobiosis have been observed. There has not been found any protective action of magnesium chloride on the cytotoxic activity of potassium bichromate on the liver cell.
给大鼠分别按2毫克/千克和5毫克/千克体重的剂量注射重铬酸钾（K2Cr2O7），按500毫克/千克的剂量注射氯化镁（MgCl2），持续30天。这两种化合物也联合使用（K2Cr2O7 - 5毫克 + MgCl2 - 500毫克）。对肝脏进行了组织病理学以及酸性磷酸酶活性、碱性磷酸酶活性和三磷酸腺苷酶活性的组织化学检查。小剂量（2毫克）重铬酸钾未观察到变化。大剂量（5毫克）重铬酸钾时，观察到酸性磷酸酶组织化学反应增加以及出现实质性变性、肝细胞脂肪变性及其坏死等组织病理学变化。未发现氯化镁对重铬酸钾对肝细胞的细胞毒性活性有任何保护作用。
