Tateishi J, Kuroda S, Ikeda H, Otsuki S
Jpn J Med Sci Biol. 1975;28 Suppl:187-95.
Eight beagle dogs were treated orally with iodoxyquinoline (chinoform, clioquinol) again, and all of them manifested similar neurologic symptoms to those observed in our previous experiments on mongrel dogs, beagle dogs, cats and a monkey. The neurologic symptoms were identical both clinically and pathologically with those of subacute myelo-optico-neuropathy (abbreviated to SMON) in man. In the present study, the neurologic manifestations evolved with less total chinoform doses (5.1-13.8 g/kg) in shorter periods (19-47 days) and there was no difference between each group on the increasing dosage and on fixed dosage. It is discussed in the present paper that onset of the neurologic symptoms is associated with unconjugated chinoform levels in the blood.
八只比格犬再次口服碘氧喹啉（氯碘喹啉、氯碘羟喹），它们均表现出与我们之前在杂种犬、比格犬、猫和一只猴子身上所观察到的相似神经症状。这些神经症状在临床和病理上与人类亚急性脊髓视神经病（简称SMON）的症状相同。在本研究中，神经症状在总氯碘喹啉剂量较低（5.1 - 13.8 g/kg）且时间较短（19 - 47天）的情况下出现，各剂量递增组和固定剂量组之间没有差异。本文讨论了神经症状的发作与血液中未结合氯碘喹啉水平有关。
