FEDOROFF S, COOK B
J Exp Med. 1959 Jun 1;109(6):615-32. doi: 10.1084/jem.109.6.615.
When NCTC clone 929 (strain L) cells were grown either continuously or at intervals in toxic human serum, they became resistant to the toxic substance or substances. The resistance developed to toxic human serum was passed from one cell generation to another; i.e., it was heritable. The resistance to toxic human serum, developed in strain L cells, was associated with a decrease in their ability to adsorb toxic substances from the serum. This suggests that there is a decrease in the number of loci in the resistant cells where toxic substances can be bound. The resistant cells differed from the sensitive cells in their morphological appearance, the increased frequency of minute chromosomes, and the increased adhesion to glass surfaces. The cells which developed a resistance to a particular toxic serum also resisted the toxic effects of some other sera, but not of all.
当NCTC克隆929（L株）细胞在有毒的人血清中连续或间歇培养时，它们会对一种或多种有毒物质产生抗性。对有毒人血清产生的抗性会从一个细胞世代传递到另一个细胞世代，也就是说，它是可遗传的。L株细胞对有毒人血清产生的抗性与它们从血清中吸附有毒物质的能力下降有关。这表明抗性细胞中可结合有毒物质的位点数量减少。抗性细胞在形态外观、微小染色体频率增加以及对玻璃表面的粘附增加方面与敏感细胞不同。对特定有毒血清产生抗性的细胞也能抵抗其他一些血清的毒性作用，但并非所有血清。
