SJODIN R A
J Gen Physiol. 1959 May 20;42(5):983-1003. doi: 10.1085/jgp.42.5.983.
The reduction of membrane potential in frog sartorius muscle produced by rubidium and cesium ions has been studied over a wide concentration range and compared with depolarization occasioned by potassium ions. The constant field theory of passive flux has been used to predict the potential changes observed. The potential data suggest certain permeability coefficient ratios and these are compared with ratios obtained from flux data using radioactive tracers. The agreement of the flux with the potential data is good if account is taken of the inhibition of potassium flux which occurs in the presence of rubidium and cesium ions. A high temperature dependence has been observed for cesium influx (Q(10) = 2.5) which is correlated with the observation that cesium ions depolarize very little at low temperatures. The observations suggest that cesium ions behave more like sodium ions at low temperatures and more like potassium ions at room temperature with respect to their effect on the muscle cell resting potential. The constant field theory of passive ion flux appears to be in general agreement with the experimental results observed if account is taken of the dependence of permeability coefficients on the concentrations of ions used and of possible interactions between the permeabilities of ions.
在很宽的浓度范围内研究了铷离子和铯离子对青蛙缝匠肌膜电位的降低作用，并与钾离子引起的去极化作用进行了比较。利用被动通量的恒定场理论来预测所观察到的电位变化。电位数据表明了某些渗透系数比，并将这些比值与使用放射性示踪剂从通量数据中获得的比值进行了比较。如果考虑到在铷离子和铯离子存在下发生的钾通量抑制，通量与电位数据的一致性良好。已观察到铯内流具有较高的温度依赖性（Q(10)=2.5），这与在低温下铯离子几乎不引起去极化的观察结果相关。这些观察结果表明，就铯离子对肌肉细胞静息电位的影响而言，在低温下铯离子的行为更像钠离子，而在室温下更像钾离子。如果考虑到渗透系数对所用离子浓度的依赖性以及离子渗透率之间可能的相互作用，被动离子通量的恒定场理论似乎与观察到的实验结果总体上一致。
