Bloch M, Gur E, Shalev A Y
Department of Psychiatry, Hadassah University Hospital, Jerusalem, Israel.
Psychopharmacology (Berl). 1992;109(3):377-8. doi: 10.1007/BF02245887.
Twelve newly-admitted psychotic patients were treated with clinical doses of zuclopenthixol (ZPT). Plasma uric acid (PUA) was measured before and during treatment. ZPT reduced PUA in all the patients by an average of 29.6% (P < 0.0001). PUA levels during treatment correlated with those obtained before treatment (R = 0.871, P < 0.0002). PUA returned to initial levels on discontinuation of treatment. Uric acid excretion increased during treatment. It is concluded that ZPT is a potent uricosuric agent, capable of producing persistent hypouricemia while administered. Such hypouricemia might be a useful indicator of drug compliance.
12名新入院的精神病患者接受了临床剂量的珠氯噻醇（ZPT）治疗。在治疗前和治疗期间测量血浆尿酸（PUA）。ZPT使所有患者的PUA平均降低了29.6%（P < 0.0001）。治疗期间的PUA水平与治疗前测得的水平相关（R = 0.871，P < 0.0002）。停药后PUA恢复到初始水平。治疗期间尿酸排泄增加。结论是ZPT是一种有效的促尿酸排泄剂，在给药时能够产生持续性低尿酸血症。这种低尿酸血症可能是药物依从性的一个有用指标。
