Gartside S E, Cowen P J, Sharp T
MRC Unit of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK.
Psychopharmacology (Berl). 1992;109(1-2):251-3. doi: 10.1007/BF02245511.
L-Valine competes with tryptophan for transport into the brain and has previously been shown to decrease brain 5-HT synthesis. In the present study, the effect of L-valine on electrically evoked hippocampal 5-HT release was determined in the anaesthetized rat using microdialysis. In control animals two electrical stimulations of the dorsal raphe nucleus 120 min apart (S1 and S2, respectively) released similar amounts of 5-HT. In contrast, in animals which received L-valine (200 mg/kg) between stimulations, S2 released a significantly smaller amount of 5-HT than did S1, although basal 5-HT release was unchanged. The data demonstrate that L-valine decreases the electrically-evoked release of 5-HT in hippocampus in vivo.
L-缬氨酸与色氨酸竞争进入大脑的转运过程，并且此前已表明它会降低大脑中5-羟色胺（5-HT）的合成。在本研究中，使用微透析法在麻醉大鼠中测定了L-缬氨酸对电诱发的海马体5-HT释放的影响。在对照动物中，相隔120分钟对中缝背核进行两次电刺激（分别为S1和S2）释放出相似量的5-HT。相比之下，在两次刺激之间接受L-缬氨酸（200毫克/千克）的动物中，尽管基础5-HT释放未改变，但S2释放的5-HT量明显少于S1。数据表明，L-缬氨酸在体内会降低海马体中电诱发的5-HT释放。
