Mueckler M M
Washington University School of Medicine, Department of Cell Biology and Physiology, St. Louis, MO 63110.
Curr Opin Nephrol Hypertens. 1992 Oct;1(1):12-20. doi: 10.1097/00041552-199210000-00004.
Recent advances concerning the function and regulation of the facilitative and sodium-dependent glucose transport proteins are discussed. Physiologic roles have been proposed for GLUT3 and GLUT5 in the brain and intestine, respectively. Cell biologists are beginning to elucidate the subcellular trafficking pathways of GLUT4 in insulin-responsive cells. New members of the SGLT family, including a sodium-nucleoside cotransporter, have been identified.
本文讨论了易化型和钠依赖型葡萄糖转运蛋白的功能及调节方面的最新进展。已提出GLUT3和GLUT5分别在脑和肠道中发挥生理作用。细胞生物学家开始阐明胰岛素反应性细胞中GLUT4的亚细胞转运途径。已鉴定出SGLT家族的新成员，包括一种钠核苷共转运体。
