TASHIAN R E
Science. 1959 Jun 5;129(3362):1553. doi: 10.1126/science.129.3362.1553.
The oral administration of phenylpyruvic acid to human subjects results in increased urinary excretion of o-hydroxyphenylacetic acid. This demonstrates that phenylpyruvic acid may act as a precursor for o-hydroxy derivatives of phenylalanine and suggests that the formation of o-tyrosine is not necessary to account for the excretion of o-hydroxyphenylacetic acid in phenylketonuria.
对人体受试者口服苯丙酮酸会导致尿中邻羟基苯乙酸排泄增加。这表明苯丙酮酸可能作为苯丙氨酸邻羟基衍生物的前体，并提示在苯丙酮尿症中，邻酪氨酸的形成并非解释邻羟基苯乙酸排泄所必需。
