High S
European Molecular Biology Laboratory, Heidelberg, Germany.
Bioessays. 1992 Aug;14(8):535-40. doi: 10.1002/bies.950140807.
The synthesis of biological membranes requires the insertion of proteins into a lipid bilayer. The rough endoplasmic reticulum of eukaryotic cells is a principal site of membrane biogenesis. The insertion of proteins into the membrane of the endoplasmic reticulum is mediated by a resident proteinaceous machinery. Over the last five years several different experimental approaches have provided information about the components of the machinery and how it may function.
生物膜的合成需要将蛋白质插入脂质双层中。真核细胞的糙面内质网是膜生物发生的主要场所。蛋白质插入内质网膜是由一种驻留的蛋白质机制介导的。在过去五年中，几种不同的实验方法提供了有关该机制的组成成分及其可能的运作方式的信息。
