Bucur D
Rev Chir Oncol Radiol O R L Oftalmol Stomatol Chir. 1976 Jul-Aug;25(4):303-6.
The author noted the development of tahycardia following the administration of succinylcholine, while repeated administration of the drug was followed by marked bradycardia in most of the children who received it. Administration of Pancuronium in amounts of 0,01 mg/kg of body weight, three minutes before the administration of succinylcholine resulted in the development of only very slight changes in the heart rhythm with a mean bradycardia of --0,7. Pancuronium was proved to provide prophylactic effects in rhythm disturbances occuring after intravenous reinjection of succinylcholine and this effect was superior to that obtained with d-tubocurarine.
作者注意到给予琥珀酰胆碱后出现心动过速，而在大多数接受该药的儿童中，重复给药后出现明显的心动过缓。在给予琥珀酰胆碱前三分钟，以0.01mg/kg体重的剂量给予泮库溴铵，结果仅导致心律出现非常轻微的变化，平均心动过缓为-0.7。已证明泮库溴铵对静脉再次注射琥珀酰胆碱后出现的心律失常具有预防作用，且该作用优于右旋筒箭毒碱。
