MacCabe A P, Riach M B, Kinghorn J R
Molecular Genetics Unit, University of St. Andrews, Fife, U.K.
J Biotechnol. 1991 Jan;17(1):91-7. doi: 10.1016/0168-1656(91)90029-u.
The gene coding for ACV synthetase has recently been identified and cloned. Analysis of its structure and expression, along with similar studies of other genes involved in beta-lactam biosynthesis, should lead to a better understanding of the molecular basis of regulation of the pathway and the possibility of modifying yield and diversity of fungal antibiotics.
