KRASNER R I, YOUNG G
J Exp Med. 1959 Aug 1;110(2):245-58. doi: 10.1084/jem.110.2.245.
Human plasminogen, plasma, or serum increased the pathogenicity of six streptokinase-positive streptococcal strains for mice. Combinations of commercial streptokinase and plasminogen or streptokinase and plasma did not usually increase mouse mortality to a greater degree than did plasminogen or plasma alone, suggesting that the maximal effective amount of streptokinase was produced by the organisms. The pathogenicity of Salmonella paratyphi (fibrinolysin variable) and a Group D streptococcus (streptokinase-negative) was not increased by plasminogen, plasma, or streptokinase, whereas a combination of streptokinase and plasminogen, or streptokinase and plasma did significantly increase mouse mortality resulting from these organisms. Combinations of certain concentrations of streptokinase and plasminogen increased the pathogenicity of a fibrinolysin-negative staphylococcal strain for mice to a greater extent than did either substance alone. The observed results provide evidence that streptokinase, by an interaction with plasminogen, contributes to the pathogenicity of streptokinase-positive streptococci.
人纤溶酶原、血浆或血清会增加6株链激酶阳性链球菌菌株对小鼠的致病性。商业链激酶与纤溶酶原或链激酶与血浆的组合通常不会比单独使用纤溶酶原或血浆更显著地增加小鼠死亡率，这表明生物体产生的链激酶已达到最大有效量。副伤寒沙门氏菌（纤维蛋白溶酶可变）和D组链球菌（链激酶阴性）的致病性不会因纤溶酶原、血浆或链激酶而增加，而链激酶与纤溶酶原或链激酶与血浆的组合确实会显著增加这些生物体导致的小鼠死亡率。特定浓度的链激酶和纤溶酶原的组合比单独使用任何一种物质更能增加纤维蛋白溶酶阴性葡萄球菌菌株对小鼠的致病性。观察结果证明，链激酶通过与纤溶酶原相互作用，促进链激酶阳性链球菌的致病性。
