Jain Suman, Sharma Ratna
Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi 110 029, India.
Indian J Exp Biol. 2002 Nov;40(11):1269-74.
Self-mutilation or self-injurious behaviour is a well known behavioural disorder in humans. The proposition that this behaviour in animals is a response to chronic pain of peripheral nerve injury has been met with controversy. In the present study a pharmacological model, which produces no sensory or motor loss was used to study how autotomy is related to pain. In a group of rats autotomy was induced by amphetamine in phenoxybenzamine and reserpine treated animals. The pain tests, both phasic and tonic were then performed. The results of this study showed that a total analgesia was produced in both phasic and tonic pain tests, in animals that exhibited autotomy. Injection of naloxone in these animals prevented autotomy. A correlation between autotomy and no pain is suggested in this pharmacological model of autotomy.
自残或自我伤害行为是人类中一种广为人知的行为障碍。认为动物的这种行为是对周围神经损伤慢性疼痛的反应这一观点一直存在争议。在本研究中，使用了一种不会导致感觉或运动丧失的药理学模型来研究自残与疼痛之间的关系。在一组大鼠中，在使用苯氧苄胺和利血平治疗的动物中，苯丙胺诱发了自残行为。然后进行了阶段性和持续性疼痛测试。这项研究的结果表明，在出现自残行为的动物中，阶段性和持续性疼痛测试均产生了完全镇痛效果。在这些动物中注射纳洛酮可预防自残行为。在这种自残行为的药理学模型中，提示了自残与无痛之间的相关性。
