de Perrot Marc, Keshavjee Shaf
Toronto Lung Transplant Program, Toronto General Hospital, University Health Network, University of Toronto, 200 Elizabeth Street, EN 10-224, Toronto, Ontario M5G 2C4, Canada.
Chest Surg Clin N Am. 2003 Aug;13(3):443-62. doi: 10.1016/s1052-3359(03)00055-3.
Over the past decade, improvements in the technique of lung preservation have led to significant reduction in the incidence of ischemia-reperfusion-induced lung injury after lung transplantation. The challenge remains to improve the number of donor lungs available for transplantation. While the number of patients on the waiting list is constantly increasing, only 10% to 30% of donor lungs are currently being used for transplantation. Hence, the development of new strategies to assess, repair, and improve the quality of the lungs could have a tremendous impact on the number of transplants performed. In addition, an improved understanding of the mechanisms involved in lung preservation might help elucidate the potential link between acute lung injury and chronic graft dysfunction. In the future, genetic analysis using novel technologies such as microarray analysis will help researchers determine which genes control the injury seen in the transplantation process. Hopefully, this information will provide new insights into the mechanisms of injury and reveal potential new strategies and targets for therapies to improve lung preservation.
在过去十年中，肺保存技术的改进已使肺移植后缺血再灌注诱导的肺损伤发生率显著降低。目前的挑战仍然是增加可用于移植的供体肺数量。虽然等待移植的患者数量在不断增加，但目前仅有10%至30%的供体肺被用于移植。因此，开发评估、修复和改善肺质量的新策略可能会对移植手术的数量产生巨大影响。此外，对肺保存所涉及机制的更深入了解可能有助于阐明急性肺损伤与慢性移植物功能障碍之间的潜在联系。未来，使用微阵列分析等新技术进行基因分析将帮助研究人员确定哪些基因控制移植过程中出现的损伤。有望这些信息将为损伤机制提供新的见解，并揭示改善肺保存的潜在新策略和治疗靶点。
