Rossi J J
Beckman Research Institute of the City of Hope, Duarte, California.
Curr Opin Biotechnol. 1992 Feb;3(1):3-7. doi: 10.1016/0958-1669(92)90117-2.
RNA enzymes or ribozymes are receiving considerable attention for their potential use as highly specific inhibitors of gene expression. From the basic science perspective, the mechanisms by which ribozymes catalyze site-specific cleavage (and in some cases ligation) reactions provide exciting and active areas of scientific investigation. The most recent developments in our understanding of the molecular mechanisms of catalysis, as well as in vivo applications of ribozymes, are highlighted.
RNA酶或核酶因其作为基因表达高度特异性抑制剂的潜在用途而受到广泛关注。从基础科学的角度来看，核酶催化位点特异性切割（在某些情况下还有连接）反应的机制为科学研究提供了令人兴奋且活跃的领域。本文着重介绍了我们在催化分子机制理解方面的最新进展以及核酶的体内应用。
