Akyol Nuray, Demir Tamer, Cobanoglu Bengu, Ulaş Fatih
Department of Ophthalmology, Firat University Medical School, Göz Hastaliklari AD, 23200 Elazig, Turkey.
Graefes Arch Clin Exp Ophthalmol. 2003 Oct;241(10):816-22. doi: 10.1007/s00417-003-0717-6. Epub 2003 Sep 9.
To compare the toxicities of cyclosporin A, octreotide acetate, mitomycin C and 5-fluorouracil to the ciliary body.
We applied sponges soaked in these compounds to the open scleras of rabbit eyes. Histopathological specimens were obtained from the operation site and at 180 degrees from it on the 14th day after surgery.
Mean ciliary epithelial thickness in the study groups was as follows: 12.29 +/- 2.69 microm in group 1 (mitomycin C), 13.85 +/- 4.56 microm in group 2 (5-fluorouracil), 17.71 +/- 3.09 microm in group 3 (cyclosporin A), 11.64 +/- 2.92 microm in group 4 (octreotide acetate), 11.92 +/- 2.89 microm in group 5 (topically applied octreotide acetate) and 21.85 +/- 4.29 microm in group 6 (control). The ciliary epithelial thickness in groups 1, 2, 4 and 5 was statistically different from that in the control group. Intracellular vacuolisation and degenerative changes of the non-pigmented epithelium, and pigment loss of the pigmented epithelium, were found mostly in group 1 and moderately in group 2 and 3.
Octreotide acetate and cyclosporin A are less toxic alternatives to mitomycin C and 5-fluorouracil in glaucoma filtration surgery.
比较环孢素A、醋酸奥曲肽、丝裂霉素C和5-氟尿嘧啶对睫状体的毒性。
我们将浸泡在这些化合物中的海绵应用于兔眼的开放巩膜。在手术后第14天从手术部位及其180度处获取组织病理学标本。
研究组的平均睫状体上皮厚度如下：第1组（丝裂霉素C）为12.29±2.69微米，第2组（5-氟尿嘧啶）为13.85±4.56微米，第3组（环孢素A）为17.71±3.09微米，第4组（醋酸奥曲肽）为11.64±2.92微米，第5组（局部应用醋酸奥曲肽）为11.92±2.89微米，第6组（对照组）为21.85±4.29微米。第1、2、4和5组的睫状体上皮厚度与对照组有统计学差异。非色素上皮细胞内空泡化和退行性改变以及色素上皮细胞色素丢失主要见于第1组，第2组和第3组中度出现。
在青光眼滤过手术中，醋酸奥曲肽和环孢素A是比丝裂霉素C和5-氟尿嘧啶毒性更小的替代药物。
