Krause Lothar, Hoffmann Friedrich, Zouboulis Christos C, Foerster Michael H
Department of Ophthalmology, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin, Hindenburgdamm 30, 12200 Berlin, Germany.
Graefes Arch Clin Exp Ophthalmol. 2003 Oct;241(10):871-4. doi: 10.1007/s00417-003-0754-1. Epub 2003 Sep 9.
Adamantiades-Behçet's disease is a multisystem disorder with recurrent oral and/or genital ulcerations, skin lesions, and ocular involvement. Eye involvement is a common manifestation that affects the patients' quality of life more than any other. Left untreated, it leads to blindness and often to loss of the eye through secondary complications such as phthisis or painful glaucoma.
Case report of a 24-year-old patient of Turkish descent living in Germany since his birth was admitted to our Department of Ophthalmology in 1999 because of visual loss in his right eye. He could only perceive light in that eye and evidenced total retinal detachment. In the left eye he had 20/20 vision but showed signs of retinal vascular inflammation and secondary glaucoma.
Treatment with interferon alpha (9x10(6) I.U./3x week s.c.) and prednisolone (100 mg/d p.o.) led to complete regression of the acute inflammation within 2 weeks prior to operation. Vitrectomy was then successfully performed in the right eye under the therapy of interferon alpha (9x10(6) I.U./3x week s.c.) and 10 mg prednisolone p.o. The prednisolone therapy was stopped 1 week following operation. The failure of conservative glaucoma treatment necessitated trabeculectomy in the left eye. The patient has had no further recurrence for 4 years under monotherapy with interferon alpha (3x10(6) I.U./3x week s.c.).
Interferon alpha is a potent therapy for Adamantiades-Behçet's disease with ocular involvement. It also provides a basis for safe and reliable surgical interventions. There was no intra- or perioperative recurrence of inflammation, which is a common finding in these procedures.
白塞病是一种多系统疾病，有复发性口腔和/或生殖器溃疡、皮肤病变以及眼部受累。眼部受累是一种常见表现，对患者生活质量的影响超过其他任何表现。若不治疗，会导致失明，且常常因眼球痨或疼痛性青光眼等继发并发症而失去眼球。
报告一名自出生起就居住在德国的24岁土耳其裔患者的病例。该患者于1999年因右眼视力丧失入住我们的眼科。他那只眼睛只能感知光线，且证实有视网膜全脱离。左眼视力为20/20，但有视网膜血管炎症和继发性青光眼的迹象。
用α干扰素（9×10⁶国际单位/每周3次皮下注射）和泼尼松龙（100毫克/天口服）治疗，在手术前2周内急性炎症完全消退。然后在α干扰素（9×10⁶国际单位/每周3次皮下注射）和10毫克泼尼松龙口服治疗下，右眼成功进行了玻璃体切除术。术后1周停止泼尼松龙治疗。保守治疗青光眼失败，左眼需要进行小梁切除术。该患者在α干扰素单药治疗（3×10⁶国际单位/每周3次皮下注射）下4年未再复发。
α干扰素是治疗眼部受累白塞病的有效疗法。它也为安全可靠的手术干预提供了基础。术中及围手术期均无炎症复发，而炎症复发在这些手术中是常见情况。
