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卡泊芬净挽救治疗一名可能患有侵袭性曲霉病的中性粒细胞减少患者：病例报告

Caspofungin salvage therapy in a neutropenic patient with probable invasive aspergillosis: a case report.

作者信息

Taccone F S, Marechal R, Meuleman N, Aoun M

机构信息

Intensive Care Unit (ASTI), Institut Jules Bordet, Centre des Tumeurs de l'Université Libre de Bruxelles, Brussels, Belgium.

出版信息

Support Care Cancer. 2003 Nov;11(11):742-4. doi: 10.1007/s00520-003-0522-0. Epub 2003 Sep 6.

DOI:10.1007/s00520-003-0522-0
PMID:13680323
Abstract

A 47-year-old man with acute lymphocytic leukemia was admitted in intensive care unit (ICU) because of respiratory failure. He had febrile neutropenia and probable invasive pulmonary aspergillosis (IA). Amphotericin B renal toxicity and clinical deterioration prompted a shift to caspofungin and resulted in a successful response.

摘要

一名47岁的急性淋巴细胞白血病男性因呼吸衰竭入住重症监护病房（ICU）。他患有发热性中性粒细胞减少症，可能患有侵袭性肺曲霉病（IA）。两性霉素B的肾毒性和临床病情恶化促使改用卡泊芬净，并取得了成功的疗效。

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本文引用的文献

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Voriconazole versus amphotericin B for primary therapy of invasive aspergillosis.伏立康唑与两性霉素B用于侵袭性曲霉病的初始治疗比较
N Engl J Med. 2002 Aug 8;347(6):408-15. doi: 10.1056/NEJMoa020191.
2
Antifungal activities of fluconazole, caspofungin (MK0991), and anidulafungin (LY 303366) alone and in combination against Candida spp. and Crytococcus neoformans via time-kill methods.氟康唑、卡泊芬净（MK0991）和阿尼芬净（LY 303366）单独及联合应用通过时间杀菌法对念珠菌属和新型隐球菌的抗真菌活性。
Diagn Microbiol Infect Dis. 2002 May;43(1):13-7. doi: 10.1016/s0732-8893(02)00361-9.
3
The echinocandins, first novel class of antifungals in two decades: will they live up to their promise?
棘白菌素类药物是二十年来首批新型抗真菌药物：它们会不负所望吗？
Int J Clin Pract. 2001 Nov;55(9):633-8.
4
Defining opportunistic invasive fungal infections in immunocompromised patients with cancer and hematopoietic stem cell transplants: an international consensus.定义癌症和造血干细胞移植免疫受损患者中的机会性侵袭性真菌感染：一项国际共识。
Clin Infect Dis. 2002 Jan 1;34(1):7-14. doi: 10.1086/323335. Epub 2001 Nov 26.
5
Caspofungin.卡泊芬净
Drugs. 2001;61(8):1121-9; discussion 1130-1. doi: 10.2165/00003495-200161080-00007.