van der Wielen L A, Luyben K C
Department of Biochemical Engineering, Delft University of Technology, The Netherlands.
Curr Opin Biotechnol. 1992 Apr;3(2):130-8. doi: 10.1016/0958-1669(92)90141-5.
Fermentation processes are hampered by a variety of problems originating from the accumulation of products in the fermenter. Integration of fermentation and a primary product separation step can accelerate the product formation, improve the product yield, and facilitate downstream processing. The advantages of integrated bioprocesses, however, are counteracted by the incompatibility of the subprocesses. Over the past few years, research in this field has been directed towards the development of engineering tools to reduce integration problems, to select a suitable approach, and to predict the feasibility of the integrated process. More fundamental knowledge about metabolic pathways, control mechanisms, and process dynamics is needed in order to optimally design integrated systems.
发酵过程受到发酵罐中产物积累所引发的各种问题的阻碍。将发酵与初级产物分离步骤相结合可以加速产物形成、提高产物产量并便于下游加工。然而，集成生物过程的优势被子过程的不相容性所抵消。在过去几年中，该领域的研究一直致力于开发工程工具，以减少集成问题、选择合适的方法并预测集成过程的可行性。为了优化设计集成系统，需要更多关于代谢途径、控制机制和过程动力学的基础知识。
