ANDERSEN B R, JACKSON G G
J Exp Med. 1961 Sep 1;114(3):375-84. doi: 10.1084/jem.114.3.375.
Pyelitis with acute and chronic pyelonephritis and also primary chronic pyelitis were easily initiated in female rats by a single non-traumatic retrograde infusion of bacteria into the urinary tract. The virulence of the bacterial species and the time of observation were related to the type and extent of lesions, but pyelitis regardless of the virulence appeared to be an important factor. The apex and fornix of the renal pelvic lumen were anatomic sites of persistent pyelitis which permitted local proliferation of bacteria for long periods. Cortical and medullary lesions were anatomically related to these areas of underlying pyelitis. Spread of infection followed a pattern of contiguity rather than ascending tubular infection. The experimental model has many of the features of chronic urinary infections in man and suggests that pyelitis is an important factor in the pathogenesis of chronic pyelonephritis initiated by retrograde infection.
通过向雌性大鼠尿路进行单次非创伤性逆行细菌灌注，很容易引发伴有急慢性肾盂肾炎的肾盂炎以及原发性慢性肾盂炎。细菌种类的毒力和观察时间与病变的类型和程度相关，但无论毒力如何，肾盂炎似乎都是一个重要因素。肾盂腔的顶端和穹窿是持续性肾盂炎的解剖部位，可使细菌长期在局部增殖。皮质和髓质病变在解剖学上与这些潜在肾盂炎区域相关。感染扩散遵循连续性模式，而非沿肾小管上行感染。该实验模型具有人类慢性泌尿系统感染的许多特征，并表明肾盂炎是逆行感染引发慢性肾盂肾炎发病机制中的一个重要因素。
