• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

疟疾传播阻断疫苗。

Malaria transmission-blocking vaccines.

作者信息

Kaslow D C, Bathurst I C, Barr P J

机构信息

Molecular Vaccine Section, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

出版信息

Trends Biotechnol. 1992 Nov;10(11):388-91. doi: 10.1016/0167-7799(92)90280-9.

DOI:10.1016/0167-7799(92)90280-9
PMID:1368880
Abstract

Antibodies to surface proteins of the sexual stages of Plasmodium falciparum block completely the transmission of these malaria parasites. Transmission-blocking vaccines therefore represent a powerful and novel approach to controlling the spread of this lethal disease.

摘要

针对恶性疟原虫有性阶段表面蛋白的抗体可完全阻断这些疟原虫的传播。因此,传播阻断疫苗是控制这种致命疾病传播的一种强有力的新方法。

相似文献

1
Malaria transmission-blocking vaccines.疟疾传播阻断疫苗。
Trends Biotechnol. 1992 Nov;10(11):388-91. doi: 10.1016/0167-7799(92)90280-9.
2
A novel malaria protein, Pfs28, and Pfs25 are genetically linked and synergistic as falciparum malaria transmission-blocking vaccines.一种新型疟疾蛋白Pfs28与Pfs25存在基因关联,作为恶性疟原虫传播阻断疫苗具有协同作用。
Infect Immun. 1997 Mar;65(3):1109-13. doi: 10.1128/IAI.65.3.1109-1113.1997.
3
Immunogenicity of Plasmodium falciparum sexual stage antigens: implications for the design of a transmission blocking vaccine.恶性疟原虫有性期抗原的免疫原性:对传播阻断疫苗设计的启示
Immunol Lett. 1990 Aug;25(1-3):83-6. doi: 10.1016/0165-2478(90)90096-9.
4
Strain polymorphism of Plasmodium falciparum transmission-blocking target antigen Pfs230.恶性疟原虫传播阻断靶抗原Pfs230的株多态性
Mol Biochem Parasitol. 1993 Nov;62(1):125-7. doi: 10.1016/0166-6851(93)90186-2.
5
[Current state of the studies of malaria vaccine].[疟疾疫苗研究的现状]
Przegl Epidemiol. 1990;44(3):173-8.
6
Towards a malaria vaccine: what is in sight?迈向疟疾疫苗:前景如何?
Allergol Immunopathol (Madr). 1991 May-Jun;19(3):129-35.
7
The primary antibody response of malaria patients to Plasmodium falciparum sexual stage antigens which are potential transmission blocking vaccine candidates.疟疾患者对恶性疟原虫有性阶段抗原的初次抗体反应,这些抗原是潜在的传播阻断疫苗候选物。
Parasite Immunol. 1990 Sep;12(5):447-56. doi: 10.1111/j.1365-3024.1990.tb00980.x.
8
Towards clinical development of a Pfs48/45-based transmission blocking malaria vaccine.迈向基于 PfS48/45 的疟疾传播阻断疫苗的临床开发。
Expert Rev Vaccines. 2017 Apr;16(4):329-336. doi: 10.1080/14760584.2017.1276833. Epub 2017 Jan 9.
9
Transmission-blocking immunity to Plasmodium falciparum in malaria-immune individuals is associated with antibodies to the gamete surface protein Pfs230.疟疾免疫个体对恶性疟原虫的传播阻断免疫与针对配子表面蛋白Pfs230的抗体有关。
Parasitology. 1999 Nov;119 ( Pt 5):425-33. doi: 10.1017/s0031182099005041.
10
A novel plant-produced Pfs25 fusion subunit vaccine induces long-lasting transmission blocking antibody responses.一种新型植物生产的Pfs25融合亚单位疫苗可诱导持久的传播阻断抗体反应。
Hum Vaccin Immunother. 2015;11(1):124-32. doi: 10.4161/hv.34366. Epub 2014 Nov 1.

引用本文的文献

1
Outer membrane protein complex as a carrier for malaria transmission blocking antigen Pfs230.外膜蛋白复合物作为疟疾传播阻断抗原Pfs230的载体
NPJ Vaccines. 2019 Jul 8;4:24. doi: 10.1038/s41541-019-0121-9. eCollection 2019.
2
Acceptability of a herd immunity-focused, transmission-blocking malaria vaccine in malaria-endemic communities in the Peruvian Amazon: an exploratory study.在秘鲁亚马逊地区的疟疾流行社区中,针对群体免疫和阻断传播的疟疾疫苗的可接受性:一项探索性研究。
Malar J. 2018 Apr 27;17(1):179. doi: 10.1186/s12936-018-2328-z.
3
Assessment of Antibodies Induced by Multivalent Transmission-Blocking Malaria Vaccines.
多价传播阻断疟疾疫苗诱导抗体的评估
Front Immunol. 2018 Jan 19;8:1998. doi: 10.3389/fimmu.2017.01998. eCollection 2017.
4
Immunization with Transgenic Rodent Malaria Parasites Expressing Pfs25 Induces Potent Transmission-Blocking Activity.免疫转基因啮齿动物疟疾寄生虫表达 Pfs25 诱导有效的传播阻断活性。
Sci Rep. 2018 Jan 25;8(1):1573. doi: 10.1038/s41598-017-18831-8.
5
Impact of the Charge Ratio on the In Vivo Immunogenicity of Lipoplexes.电荷比脂质体对体内免疫原性的影响。
Pharm Res. 2017 Sep;34(9):1796-1804. doi: 10.1007/s11095-017-2187-2. Epub 2017 May 30.
6
Determinants of Malaria Transmission at the Population Level.人群水平疟疾传播的决定因素。
Cold Spring Harb Perspect Med. 2017 Dec 1;7(12):a025510. doi: 10.1101/cshperspect.a025510.
7
Transmission blocking potency and immunogenicity of a plant-produced Pvs25-based subunit vaccine against Plasmodium vivax.一种植物生产的基于Pvs25的间日疟原虫亚单位疫苗的传播阻断效力和免疫原性。
Vaccine. 2016 Jun 14;34(28):3252-9. doi: 10.1016/j.vaccine.2016.05.007. Epub 2016 May 10.
8
Potent Functional Immunogenicity of Plasmodium falciparum Transmission-Blocking Antigen (Pfs25) Delivered with Nanoemulsion and Porous Polymeric Nanoparticles.恶性疟原虫传播阻断抗原(Pfs25)与纳米乳剂和多孔聚合物纳米颗粒联合递送时具有强大的功能性免疫原性。
Pharm Res. 2015 Dec;32(12):3827-36. doi: 10.1007/s11095-015-1743-x. Epub 2015 Jun 26.
9
Genetic diversity of Plasmodium vivax and Plasmodium falciparum in Honduras.洪都拉斯间日疟原虫和恶性疟原虫的遗传多样性。
Malar J. 2012 Nov 26;11:391. doi: 10.1186/1475-2875-11-391.
10
Malaria transmission blocking immunity and sexual stage vaccines for interrupting malaria transmission in Latin America.阻断疟疾传播的免疫和性阶段疫苗,用于中断拉丁美洲的疟疾传播。
Mem Inst Oswaldo Cruz. 2011 Aug;106 Suppl 1(Suppl 1):202-11. doi: 10.1590/s0074-02762011000900025.