De Castro J, Paramentier P, Andrieu S
Ann Anesthesiol Fr. 1976;17(9):1071-86.
Before dealing with this subject, the author believes that it is useful to give a definition of this technique and justify it. He then recalls the results which he obtained with various analgesic drugs, few products permit this technique, either because of too low analgesic power, or because of the appearance in high dosage, of troublesome or dangerous side-effects. At present, in this type of anesthetic, one may use either morphine or fentanyl or fentathienyl. Analgesic anesthesia with morphine. This technique presents advantages and disadvantages. The author has no personal experience of high doses of morphine and can only report that of other authors who have studied this problem. Anesthesia analgesia with fentanyl and fentathienyl. The author believes that this technique presents advantages over the previous technique, he has personally studied the clinical pharmacology of high doses of fentanyl and he believes that this drug used by the intravenous route, at a dose of 0.05 mg/kg associated with a curare derivative, possesses favourable cardiovascular and respiratory metabolic effects during the surgical operation, but one must recognize that +/-20 p. 100 of cases, fentanyl associated only with curare is not sufficient to give a stable anesthetic. At present, the author has replaced, in his technique, fentanyl by fentathienyl which is a morphine derivative 6 to 7 times more powerful. He found with this drug most of the properties of high doses of fentanyl but the analgesia obtained is deeper, one does not find more than 20 p. 100 of resistant cases. However, the author noted the fairly frequent appearance of tachycardia for which there was no valid explanation. In conclusion. The author believes that in the reproaches which are made to analgesic anesthesia, some are justified, others are less so. It requires prolonged post-operative supervision, but the latter would be advisable for any other type of anesthesia. It dose not always permit one, in its pure form, to obtain stable anesthesia, but this is less and less true with the appearance of more and more powerful derivatives. The use of analgesic anesthesia as a routine technique is only possible in the form of sequential analgesic anesthesia, a technique which uses an antimorphine drug to awaken the patient. In this field, various new products are presented are discussed.
在探讨这个主题之前,作者认为对这项技术进行定义并阐述其合理性是很有必要的。然后他回顾了使用各种镇痛药物所取得的结果,由于镇痛效果太差,或者因高剂量使用时会出现麻烦或危险的副作用,很少有产品适用于这项技术。目前,在这类麻醉中,可以使用吗啡、芬太尼或苯噻啶基芬太尼。吗啡镇痛麻醉。这项技术有其优缺点。作者本人没有使用高剂量吗啡的经验,只能报告其他研究过这个问题的作者的经验。芬太尼和苯噻啶基芬太尼镇痛麻醉。作者认为这项技术比之前的技术更具优势,他本人研究过高剂量芬太尼的临床药理学,他认为静脉注射剂量为0.05毫克/千克的这种药物与一种箭毒衍生物联合使用时,在手术过程中具有良好的心血管和呼吸代谢作用,但必须认识到,在±20%的病例中,仅与箭毒联合使用的芬太尼不足以产生稳定的麻醉效果。目前,作者在其技术中已用苯噻啶基芬太尼取代了芬太尼,苯噻啶基芬太尼是一种效力比吗啡强6至7倍的衍生物。他发现这种药物具有高剂量芬太尼的大部分特性,但所获得的镇痛效果更深,耐药病例不超过20%。然而,作者注意到心动过速相当频繁地出现,对此尚无合理的解释。总之。作者认为,在对镇痛麻醉的指责中,有些是有道理的,有些则不然。它需要术后长时间的监护,但这对任何其他类型的麻醉也是可取的。它并不总是能单纯依靠自身获得稳定的麻醉效果,但随着越来越强效的衍生物的出现,这种情况越来越少见了。将镇痛麻醉作为常规技术使用,只能采用序贯镇痛麻醉的形式,这是一种使用抗吗啡药物唤醒患者的技术。在这个领域,有各种新产品被展示和讨论。