Gennity J M, Inouye M
University of Medicine and Dentistry of New Jersey, Piscataway.
Curr Opin Biotechnol. 1991 Oct;2(5):661-7. doi: 10.1016/0958-1669(91)90031-y.
Most secretory proteins are synthesized as precursors with an amino-terminal signal peptide. Genetic identification of proteins essential for signal peptide dependent translocation to the Escherichia coli periplasm has led to the biochemical dissection of the secretion pathway. Additional mechanisms exist in Gram-negative bacteria for protein secretion to the extracellular environment.
大多数分泌蛋白作为具有氨基末端信号肽的前体被合成。对信号肽依赖性转运至大肠杆菌周质所必需的蛋白质进行基因鉴定，已促成了分泌途径的生化剖析。革兰氏阴性菌中还存在将蛋白质分泌到细胞外环境的其他机制。
