Ono J, Walson P D
Department of Pediatrics, Ohio State University, Children's Hospital 43205, USA.
Med J Osaka Univ. 1991 Mar;40(1-4):45-9.
We investigated the effects of different injection intervals, (24 hr, 48 hr, and 72 hr) on the development of kindled seizures induced by repetitive pentylenetetrazol (PTZ) injections (30 mg/kg) in rats. Regardless of injection interval, kindled seizures were obtained 1 week after the completion of consecutive PTZ injections. This PTZ kindled seizure model appears to mimick generalized seizure and be useful in the investigation of seizure phenomenon. With 48 and 72 hr injection interval, the seizure responses gradually increased with consecutive injections. The convulsive severity of 24 hr interval group showed a transient increased and then stabilized at a low score (2/6). This difference between these injection interval might reflect the appearance of some short of inhibition during the more closely spaced (24 hr) repeated injections.
我们研究了不同注射间隔时间（24小时、48小时和72小时）对大鼠重复注射戊四氮（PTZ，30毫克/千克）诱导的点燃性癫痫发作发展的影响。无论注射间隔如何，在连续PTZ注射完成1周后均出现点燃性癫痫发作。这种PTZ点燃性癫痫发作模型似乎可模拟全身性癫痫发作，并且在癫痫发作现象的研究中有用。在48小时和72小时注射间隔时，癫痫发作反应随着连续注射而逐渐增加。24小时间隔组的惊厥严重程度显示出短暂增加，然后稳定在低分（2/6）。这些注射间隔之间的差异可能反映了在间隔更近（24小时）的重复注射期间出现了某种程度的抑制。
