Mathé G, Chenu E, Bourut C
Institut du Cancer et d'Immunogénétique, Hôpital Paul-Brousse, Villejuif, France.
Biomed Pharmacother. 1990;44(1):1-3. doi: 10.1016/0753-3322(90)90061-d.
As we had discovered the virostatic effects of some analogues of acriflavine, a non-oncostatic intercalating agent, on HIV1 and on its best murine model, Friend's virus [7], we then studied other non- or poorly oncostatic intercalating agents, in particular ellipticins (whose negligible cytostatic effect with methoxy-9-ellipticin we first published. We report in this paper the in vivo virostatic effect of 2-methyl-9-hydroxy-ellipticinium (elliptinium) on Friend's virus.
由于我们已经发现了吖啶黄素（一种非致癌性嵌入剂）的某些类似物对HIV1及其最佳小鼠模型——Friend病毒的抑制病毒作用[7]，于是我们研究了其他非致癌或低致癌性嵌入剂，特别是玫瑰树碱（我们首次发表了关于甲氧基-9-玫瑰树碱可忽略不计的细胞抑制作用）。我们在本文中报告了2-甲基-9-羟基玫瑰树碱（玫瑰树碱）对Friend病毒的体内抑制病毒作用。
