thaliblastine对小鼠可移植肿瘤的作用。
Effect of thaliblastine on transplantable tumours in mice.
作者信息
Mircheva J, Stoychkov J
出版信息
Biomedicine. 1976 Sep 30;25(8):280-1.
PMID:137002
Abstract
The antitumour activity of the alkaloid thaliblastine was studied on 7 ascitic and solid transplantable tumours in mice. It was found that the compound has a pronounced antitumour effect on ascitic tumour of Ehrlich, NK/Ly lymphoma (i.p.), sarcoma 37 (s.c. and i.p.), sarcoma 180 (s.c.) and Lewis lung carcinoma (i.m.). With a number of tumours, it was found that the single and intermittent drug administration exerts a better therapeutic effect than the chronic treatment.
摘要
对生物碱thaliblastine在7种小鼠腹水型和实体型可移植肿瘤上的抗肿瘤活性进行了研究。发现该化合物对艾氏腹水瘤、NK/Ly淋巴瘤（腹腔注射）、肉瘤37（皮下和腹腔注射）、肉瘤180（皮下）和刘易斯肺癌（肌肉注射）有明显的抗肿瘤作用。对于多种肿瘤，发现单次和间歇给药比长期给药具有更好的治疗效果。
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