Epitope mapping in Salmonella flagellar protein.

The flagellar filaments of bacteria of the genus Salmonella are highly immunopotent and antigenically diverse. It is proposed to develop vaccines by replacing the flagella of live attenuated Salmonella strains with engineered flagellar filament proteins containing foreign epitopes of medical and agricultural importance. As an initial step in this process, the major linear epitope regions of one filament protein have been identified.