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相似文献

1
Damage by visible light to the acridine orange--DNA complex.可见光对吖啶橙-DNA复合物的损伤。
Biophys J. 1961 May;1(5):389-400. doi: 10.1016/s0006-3495(61)86897-5.
2
The interaction of deoxyribonucleic acid and acridine orange.脱氧核糖核酸与吖啶橙的相互作用。
Arch Biochem Biophys. 1962 Jan;96:47-50. doi: 10.1016/0003-9861(62)90448-4.
3
Anomalous rotatory dispersion of acridine orange-native deoxyribonucleic acid complexes.吖啶橙-天然脱氧核糖核酸复合物的异常旋光色散
Biochim Biophys Acta. 1961 Jun 24;50:397-9. doi: 10.1016/0006-3002(61)90354-7.
4
Spectrophotometric studies on the binding of acridine orange to ribonucleic acid and deoxyribonucleic acid.吖啶橙与核糖核酸及脱氧核糖核酸结合的分光光度研究。
Biochim Biophys Acta. 1960 Apr 22;39:547-50. doi: 10.1016/0006-3002(60)90216-x.
5
Effects of light and optical sensitization by acridine-orange on living bull spermatozoa.
Nature. 1961 Jan 7;189:76-8. doi: 10.1038/189076b0.
6
THERMAL DENATURATION OF DEOXYRIBONUCLEIC ACID-ACRIDINE ORANGE COMPLEXES.脱氧核糖核酸-吖啶橙复合物的热变性
Biochim Biophys Acta. 1964 Nov 15;91:539-40. doi: 10.1016/0926-6550(64)90088-x.
7
[USE OF ACRIDINE ORANGE, A LUMINESCENT DYE, FOR THE STUDY ON SECONDARY STRUCTURES OF NUCLEIC ACIDS].[吖啶橙（一种发光染料）在核酸二级结构研究中的应用]
Biofizika. 1965;10:32-6.
8
Aggregation of an acridine dye on native and denatured deoxyribonucleates.吖啶染料在天然和变性脱氧核糖核酸上的聚集。
Nature. 1959 Dec 19;184:1920-2. doi: 10.1038/1841920a0.
9
Acridine orange staining of a single-stranded DNA bacteriophage.单链DNA噬菌体的吖啶橙染色
Virology. 1961 Jun;14:264-6. doi: 10.1016/0042-6822(61)90202-1.
10
OPTICAL ROTATORY POWER OF DNA AND OF ITS COMPLEX WITH ACRIDINE ORANGE UNDER STREAMING CONDITIONS.
Nature. 1964 Oct 31;204:468-70. doi: 10.1038/204468b0.

引用本文的文献

1
An introduction to transcription and gene regulation.转录与基因调控简介。
J Biol Chem. 2010 Aug 20;285(34):25885-92. doi: 10.1074/jbc.X110.143867. Epub 2010 May 28.
2
INTERACTION OF NUCLEIC ACIDS, II. CHEMICAL LINKAGE OF THE CARCINOGEN 3,4-BENZPYRENE TO DNA INDUCED BY PHOTORADIATION.核酸的相互作用，II. 光辐射诱导致癌物3,4-苯并芘与DNA的化学连接
Proc Natl Acad Sci U S A. 1964 Feb;51(2):272-80. doi: 10.1073/pnas.51.2.272.
3
Dye-sensitized photoinactivation of yeast in relation to the x-ray oxygen effect.酵母的染料敏化光灭活与X射线氧效应的关系
Proc Natl Acad Sci U S A. 1962 Oct 15;48(10):1738-45. doi: 10.1073/pnas.48.10.1738.
4
Letters to the editor.致编辑的信。
Biophys J. 1963 Jan;3(1):97-8. doi: 10.1016/s0006-3495(63)86806-x.
5
Molecular facets of mitotic regulation. II. Factors underlying the removal of thymidine kinase.有丝分裂调控的分子层面。II. 胸苷激酶去除的潜在因素。
Proc Natl Acad Sci U S A. 1963 Jun;49(6):861-5. doi: 10.1073/pnas.49.6.861.
6
Effect of acriflavin on the kinetoplast of Leishmania tarentolae. Mode of action and physiological correlates of the loss of kinetoplast DNA.吖啶黄素对热带利什曼原虫动基体的作用。动基体DNA丢失的作用方式及生理关联。
J Cell Biol. 1968 Jun;37(3):660-82. doi: 10.1083/jcb.37.3.660.
7
Purification and staining of intact yeast DNA chromosomes and real-time observation of their migration during gel electrophoresis.完整酵母DNA染色体的纯化与染色及其在凝胶电泳过程中迁移的实时观察
Biochem J. 1997 Aug 15;326 ( Pt 1)(Pt 1):131-8. doi: 10.1042/bj3260131.
8
Real-time imaging of the reorientation mechanisms of YOYO-labelled DNA molecules during 90 degrees and 120 degrees pulsed field gel electrophoresis.YOYO标记的DNA分子在90度和120度脉冲场凝胶电泳过程中重新定向机制的实时成像。
Nucleic Acids Res. 1996 Dec 1;24(23):4759-67. doi: 10.1093/nar/24.23.4759.
9
[The photodynamic effect of thiopyronin on nucleic acids].[硫代吡咯宁对核酸的光动力效应]
Biophysik. 1966;3(3):241-8. doi: 10.1007/BF01190625.
10
Antimutagenic activity of actinomycin D and basic fuchsine in Saccharomyces cerevisiae.放线菌素D和碱性品红在酿酒酵母中的抗诱变活性。
Mol Gen Genet. 1968;103(3):248-52. doi: 10.1007/BF00273695.

本文引用的文献

1
STRAND SEPARATION AND SPECIFIC RECOMBINATION IN DEOXYRIBONUCLEIC ACIDS: PHYSICAL CHEMICAL STUDIES.脱氧核糖核酸中的链分离与特异性重组：物理化学研究
Proc Natl Acad Sci U S A. 1960 Apr;46(4):461-76. doi: 10.1073/pnas.46.4.461.
2
THE RELATIVE HOMOGENEITY OF MICROBIAL DNA.微生物DNA的相对同质性。
Proc Natl Acad Sci U S A. 1959 Jul;45(7):1039-43. doi: 10.1073/pnas.45.7.1039.
3
THE PROPERTIES OF SONIC FRAGMENTS OF DEOXYRIBOSE NUCLEIC ACID.脱氧核糖核酸的声波片段特性
Proc Natl Acad Sci U S A. 1958 May;44(5):432-8. doi: 10.1073/pnas.44.5.432.
4
Complex formation between adenine oligonucleotides and polyuridylic acid.腺嘌呤寡核苷酸与聚尿苷酸之间的复合物形成。
Biochim Biophys Acta. 1960 Jun 17;41:175-7. doi: 10.1016/0006-3002(60)90394-2.
5
Inactivation by visible light of yeast sensitized by a nucleic acid fluorochrome.
Nature. 1960 May 28;186:731-2. doi: 10.1038/186731b0.
6
Effect of nitric oxide on the production of chromosomal aberrations by x-rays.一氧化氮对X射线诱导染色体畸变产生的影响。
Exp Cell Res. 1959 Jun;17(3):588-90. doi: 10.1016/0014-4827(59)90095-3.
7
Similarity of the structure of DNA from a variety of sources.来自各种来源的DNA结构的相似性。
J Biophys Biochem Cytol. 1959 May 25;5(3):397-404. doi: 10.1083/jcb.5.3.397.
8
Distribution of proflavin-induced mutations in the genetic fine structure.原黄素诱导突变在基因精细结构中的分布
Nature. 1958 Oct 11;182(4641):983-5. doi: 10.1038/182983a0.
9
Inhibition and activation of polynucleotide phosphorylase through the formation of complexes between acridine orange and polynucleotides.通过吖啶橙与多核苷酸形成复合物来抑制和激活多核苷酸磷酸化酶。
Nature. 1958 Jul 26;182(4630):242-4. doi: 10.1038/182242a0.

可见光对吖啶橙-DNA复合物的损伤。

Damage by visible light to the acridine orange--DNA complex.

作者信息

FREIFELDER D, DAVISON P F, GEIDUSCHEK E P

出版信息

Biophys J. 1961 May;1(5):389-400. doi: 10.1016/s0006-3495(61)86897-5.

DOI:10.1016/s0006-3495(61)86897-5
PMID:13701685
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1366317/
Abstract

Salmon DNA has been irradiated with visible light in the presence of acridine orange. If the dye is bound to the DNA, there results: (a) a decrease in sedimentation coefficient, (b) a lowering of viscosity, and (c) a decrease in the thermal denaturation temperature. CsCl banding experiments show that the first two effects reflect depolymerization of the DNA. Depolymerization apparently occurs by single-strand scission although some double-strand scission is not excluded. The destabilization of secondary structure results probably from chemical attack on the components of the individual strands.

摘要

在吖啶橙存在的情况下，鲑鱼脱氧核糖核酸（DNA）已用可见光进行了照射。如果该染料与DNA结合，会产生以下结果：（a）沉降系数降低，（b）粘度下降，以及（c）热变性温度降低。氯化铯密度梯度离心实验表明，前两种效应反映了DNA的解聚。解聚显然是通过单链断裂发生的，尽管不排除一些双链断裂的情况。二级结构的不稳定可能是由于对单链成分的化学攻击所致。