GAINES S, LANDY M, EDSALL G, MANDEL A D, TRAPANI R J, BENENSON A S
J Exp Med. 1961 Sep 1;114(3):327-42. doi: 10.1084/jem.114.3.327.
A study was made of the efficacy of various antityphoid immunizing agents in immunizing chimpanzees against typhoid fever produced by feeding viable S. typhosa. It was found that both acetone-killed and heat-killed, phenol-preserved typhoid vaccines were effective in protecting against infection induced with either homologous or heterologous strains of typhoid bacilli. Purified O antigen induced no discernible protection, but some immunity was afforded by the administration of purified Vi antigen.
对各种抗伤寒免疫制剂在使黑猩猩抵御因喂食活伤寒杆菌而引发的伤寒热方面的功效进行了一项研究。发现丙酮灭活和热灭活、苯酚保存的伤寒疫苗在预防同源或异源伤寒杆菌菌株引起的感染方面均有效。纯化的O抗原未诱导出明显的保护作用,但给予纯化的Vi抗原可提供一定的免疫力。