伤寒沙门氏菌Vi抗原与伤寒免疫力。11. 人体安全性与抗原性
Vi antigen from Salmonella typhosa and immunity against typhoid fever. 11. Safety and antigenicity in humans.
作者信息
Levin D M, Wong K H, Reynolds H Y, Sutton A, Northrup R S
出版信息
Infect Immun. 1975 Dec;12(6):1290-4. doi: 10.1128/iai.12.6.1290-1294.1975.
Abstract
Safety and antigenicity of a purified preparation of Salmonella typhosa Vi antigen was evaluated in human volunteers. Dosages of Vi antigen at 25, 50, and 100 mug were less toxic than U.S. standard typhoid vaccine (lot 6A) containing 5 X 10(8) bacteria per dosage. Vi antigen in comparison with the standard typhoid vaccine induced higher hemagglutinating antibody but lower bactericidal antibody responses.
摘要
在人类志愿者中评估了伤寒沙门氏菌Vi抗原纯化制剂的安全性和抗原性。25微克、50微克和100微克剂量的Vi抗原的毒性低于美国标准伤寒疫苗（6A批次），后者每剂含有5×10⁸个细菌。与标准伤寒疫苗相比，Vi抗原诱导产生更高的血凝抗体，但杀菌抗体反应较低。
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