Brunet C, Bédard P M, Lavoie A, Jobin M, Hébert J
Centre de Recherche en Inflammation et Immunologie-Rhumatologie, Le Centre Hospitalier de l'Université Laval, Ste-Foy, Quebec, Canada.
J Allergy Clin Immunol. 1992 Jan;89(1 Pt 1):87-94. doi: 10.1016/s0091-6749(05)80044-2.
A number of cytokines, including histamine-releasing factors (HRFs), have a role to play in IgE-mediated asthma. However, the influence of HRF in allergic rhinitis without asthma remains to be revealed. This article presents a double-blind, placebo-controlled study on the role of HRF in ragweed-allergic rhinitis and its modulation by natural pollen exposure and specific immunotherapy (IT). Twenty-seven patients allergic to ragweed were randomly assigned to receive either preseasonal alum-precipitated aqueous extracts of ragweed or placebo. Before the onset of therapy and during the ragweed-pollen season, subjects were evaluated for each of the following: clinical scores, ragweed IgE and IgG antibody levels, and spontaneous and allergen-driven HRF production. Thirteen nonatopic volunteers were also studied in the same protocol. First, before the initiation of therapy, more HRF was produced by both unstimulated and ragweed-stimulated mononuclear cells (MNCs) of atopic subjects as compared to MNCs of nonatopic subjects. Second, MNCs of the placebo-treated group produced significantly more spontaneous and ragweed-specific HRF during the pollen season compared to the preseasonal values. Finally, specific IT not only improved the clinical manifestation of allergy but also prevented the seasonal rise of spontaneous and ragweed-driven HRF production, along with a well-known change in other immunologic parameters associated with successful IT.
包括组胺释放因子（HRFs）在内的多种细胞因子在IgE介导的哮喘中发挥作用。然而，HRF在无哮喘的变应性鼻炎中的影响仍有待揭示。本文介绍了一项关于HRF在豚草变应性鼻炎中的作用及其受天然花粉暴露和特异性免疫疗法（IT）调节的双盲、安慰剂对照研究。27名豚草过敏患者被随机分配接受季节性前明矾沉淀的豚草水提取物或安慰剂。在治疗开始前和豚草花粉季节期间，对受试者进行以下各项评估：临床评分、豚草IgE和IgG抗体水平，以及自发和变应原驱动的HRF产生。13名非特应性志愿者也按照相同方案进行了研究。首先，与非特应性受试者的单核细胞（MNCs）相比，特应性受试者未受刺激和经豚草刺激的MNCs产生的HRF更多。其次，与季节性前的值相比，安慰剂治疗组的MNCs在花粉季节产生的自发和豚草特异性HRF明显更多。最后，特异性IT不仅改善了过敏的临床表现，还阻止了自发和豚草驱动的HRF产生的季节性升高，同时还伴随着与成功IT相关的其他免疫参数的众所周知的变化。
